Mrs May will attempt to win support from European businesses for her goal of moving the negotiations on to trade talks.
During the event, which the Confederation of British Industry has helped organise, Mrs May will set out her vision of a “bold and deep economic partnership” between the UK and EU after the country leaves the bloc.
Groups represented include the BDI and BDA from Germany, Medef from France and the EU-wide BusinessEurope.
The Brexit Secretary David Davis and Business Secretary Greg Clark will also attend the Downing Street event.
A leaders’ summit will take place next month and the European Union’s chief negotiator Michel Barnier has previously said the moment was approaching for a “real clarification” of Britain’s position on issues such as citizens’ rights, the Irish border and the UK’s financial settlement.
If the 27 remaining EU members agree next month that sufficient progress has been made on these issues, they will give a green light for negotiations to move on to the questions of trade and transition to a new post-Brexit negotiation.