Theresa May will give her keynote speech on Wednesday, October 3 at 10am in Symphony Hall at the International Convention Centre (ICC) in Birmingham.
The Prime Minister will give her address on the final day of the event.
She is expected to issue support for her Chequers proposal on Brexit and hope to discredit Boris Johnson who has repeatedly attacked her Brexit policies.
Last year, Mrs May famously struggled with her speech as she battled with an ongoing cough and had to pause while she had a drink of water.
She was given supportive applause by Tory activists as she carried on with the speech, but to make matters worse comedian Lee Nelson interrupted her to give her a fake P45 tax form supposedly from “Boris.”
And then in further bad luck, a letter fell from the stage backdrop behind her.
Mrs May is hoping this year’s speech runs more smoothly and goes off with less glitches.
After Mrs May’s speech, there will be speeches from International Trade Secretary Liam Fox, International Development Secretary Penny Mordaunt, Defence Secretary Gavin Williamson, and Foreign Secretary Jeremy Hunt.
Meanwhile former Foreign Secretary Boris Johnson addressed the conference at a fringe event in which he criticised Theresa May’s Brexit plans.
He said Mrs May needed “to chuck Chequers” and has become one of the PM’s loudest critics after resigning from the party in July.
Mr Johnson told the Conservative supporters who had queued to get a seat in the 1,500-seat conference hall “do not relive them when they say there is no other plan and no alternative.”
He said: “This is the moment to chuck Chequers. If we cheat the electorate and Chequers is a cheat, we will escalate that sense of mistrust.”
The former Mayor of London said Mrs May’s Chequers plan for leaving the EU was “not what we voted for.”
To a huge crowd from the crowd he said: “Now is the time to chuck Chequers.”
Asked on BBC Now Breakfast what her relationship with Mr Johnson was like, Mrs May said: “Well, I’m sure that’s going to be a very lively event this evening.
“At this conference what we’re focusing on is the opportunity for this country once we leave the European Union and the opportunity that we want to ensure that people in this country have.”
Mrs May said she is not ready to hand over the reins of power and said she was in the party “for the long term.”
She told BBC Radio 4’s Today programme: “I’m in this for the long term, not just for the Brexit deal but actually for the domestic agenda we are setting out at this conference.”
Theresa May’s keynote speech will be live streamed by Sky News from 10am.