The Prime Minister is heading to Brussels for an EU summit where Brexit, immigration and the ongoing refugee crisis are all set to be on the agenda.
A dinner meeting scheduled for 8pm means the European leaders will miss the final games of the group stages of the tournament.
Despite being away from a screen, the Prime Minister may be updated about the game.
England are currently sitting at the top of their group, having won both of their games so far and had fewer yellow cards than Belgium.
A senior official said they could “make her aware” of the score “if needs be”.
The Prime Minister, who has agreed for the cross of St George to fly over 10 Downing Street, is unlikely to be able to catch any of the action as she locks horns with counterparts including Belgium’s Charles Michel at the summit.
The Prime Minister congratulated the England team on their winning ways in the tournament so far in Parliament on Wednesday.
Speaking at Prime Minister’s Questions, Mrs May congratulated Gareth Southgate and his squad for making it through to the round of 16.
The team’s place beyond the group stage was guaranteed following their 6-1 win over Panama on Sunday.
Mrs May told MPs: “Number 10 will be flying the England flag on the day of each of England’s matches from now on.
“We will be encouraging other government departments to do the same.”
The PM promised the move would not be a temporary measure, and said she would be following suit for the Women’s World Cup next year.
She continued: “I’m going to go further than my predecessors.
“Next year we will do the same for the Women’s World Cup.”
There was a record breaking TV audience for England’s record breaking win over Panama on Sunday.
More than 14million people watched Harry Kane score a hat-trick and give England their highest ever score in a World Cup game.
Pubs and living rooms are expected to be full of England fans again for tonight’s final game against their European rivals.