The panelists discuss everything on the panel show, sharing everything from their previous divorces to their sex lives, with a series of celebrity guests.
And Jane Moore, Saira Khan and Coleen Nolan have revealed their off-screen personas are just as wild as they seem.
Speaking exclusively to OK! Online, the ITV stars lifted the lid on their fun nights out.
Jane joked: “Have you tried getting Coleen out?”
“I stay in a hotel when I’m doing the show and it’s bliss,” Jake Roche’s mum explained.
“No kids and I don’t have to cook, clean, iron, nothing!”
Andrea McLean and her fiancé Nicholas share a snap outside of Buckingham Palace [Instagram]
“I once visited Coleen in her hotel and stayed up till 3am – drinking tea,” Saira replied.
However, the trio revealed when they do venture out, they have been known to get banned from restaurants for their raucous antics.
“The biggest drinkers are me and Nadia [Sawalha],” Jane continued. “Two glasses and Nadia’s off. There are restaurants all over London we can no longer frequent.
Saira added: “Nadia goes back to being an 18-year-old student. She’s the life and soul.”
Loose Women airs daily at 12:30pm, on ITV.