This week’s episode was filmed in Exeter and the question posed to the panel was whether the Prime Minster’s cabinet was so divided it was taking the UK towards a no deal Brexit.
The Loose Women host rejected calls for a second vote and said it was not how a democracy works, despite her support for the EU.
She said: “The result of that has been that it’s bred enormous frustration in the public at large.
“It’s led to things like the march last weekend, where people are now asking for a second referendum on the terms.
“It’s tragic really, because we can’t go forward in this country running democracy on a series of referendums.
“So every time we have a referendum and we don’t like the result we have another referendum, well that’s plainly ludicrous.”
But she also blasted Theresa May’s Government for lack of leadership and guidance through the Brexit negotiations.
She added: “Government should work in a democracy to trust and empower our MPs to carry out our wishes in a civilised and dignified fashion.
“But sadly they are offering no leadership at the moment and you can just sense the anger in the country.”
The journalist also made a strange analogy which evoked the Beatle’s psychedelic album “Magical Mystery Tour” to describe the Brexit negotiation process.
She said: “I think that most of the public look at the goings on in cabinet and they just can’t believe what’s happening.
“Most of us feel like we got on a magical mystery tour coach when the referendum result was announced.
“It’s like we’ve gone round and round a roundabout and the driver of the bus, Theresa May, isn’t anywhere nearer to getting to a conclusion.”
Her comments come after rifts within the Government after Jeremy Hunt and Boris Johnson criticised business leaders for allegedly blackmailing the UK by threatening to leave post-Brexit.
This prompted Business Secretary Greg Clark to hit out at his colleagues and insist they had legitimate concerns.
Up to 100,000 people protested in London on Saturday calling for a ‘People’s Vote’ on the Brexit deal the UK negotiates with the EU.
The demonstration was dubbed the ‘March for a People’s Vote’ and speakers at the event included Liberal Democrat leader Sir Vince Cable, Tory rebel Anna Soubry, Labour MP David Lammy and Green Party’s Caroline Lucas.
Gina Miller, who took the Government to court over the triggering of Article 50, said: “It is simply dishonest for them in that House to say that they still believe the will of the people is the same as it was two years ago.