Dementia: Single vaccine to treat Alzheimer’s as well as skin disease

Posted on Oct 24 2017 - 12:53am by admin

British researchers have combined the tetanus vaccine with a viral particle that usually affects cucumbers, forming a compound that stimulates the immune system. 

Tests have both helped treat diseases like psoriasis and some allergies, while also raising antibody levels believed to help prevent forms of dementia including Alzheimer’s. 

Scientists are set to begin human trials of the vaccine, having received regulatory approval. 

They believe the study could help spare hundreds of thousands of people from the ravages of chronic disease.

The team, led by Dundee University’s Dr John Foerster and Oxford’s Prof Martin Bachmann, first took the protein coat of cucumber mosaic virus. 

They then incorporated a protein derived from the tetanus vaccine that is known to stimulate the body’s immune system. 

It is believed the new vaccine will be effective against many chronic diseases including psoriasis and Alzheimer’s. 

Mr Bachmann, Professor of Vaccinology at the Jenner Institute in Oxford, added: “Alzheimer’s disease usually develops in elderly people. 

“The fact that the vaccine described here is optimised for old individuals seems therefore particularly helpful.” 

As well as being preventative the vaccine can be therapeutic, meaning it can cure a disease such as psoriasis after it has already been established.

Antibodies for psoriasis currently need to be injected at least once a month and cost about £10,000 a year. 

A vaccine could offer a much more affordable treatment. 

Dr Foerster said: “The idea is pretty simple – by creating a vaccine that stimulates us to make antibodies… we can replace the need for frequent and expensive injections and make this type of treatment much more affordable and accessible to patients.” 

The paper has been published in the journal Nature Vaccines.

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